SFP1 zinc-coordinating transcription factor SFP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SFP1
Official Full Name: zinc-coordinating transcription factor SFP1
Primary source: SGD:S000004395
Locus tag: YLR403W
See related: AllianceGenome:SGD:S000004395; FungiDB:YLR403W; VEuPathDB:YLR403W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in positive regulation of ribosomal protein gene transcription by RNA polymerase II and regulation of cell size. Located in cytoplasm and nucleus. Orthologous to human JAZF1 (JAZF zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See SFP1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (925568..927619)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sfp1 controls TRA1 expression, linking TORC1 and cell growth regulation to the SAGA acetyltransferase complex during misfolded protein stress.
Title: Sfp1 links TORC1 and cell growth regulation to the yeast SAGA-complex component Tra1 in response to polyQ proteotoxicity.
Sfp1 controls cell size by coordinating expression of genes implicated in mass accumulation and cell division.
Title: Sfp1 regulates transcriptional networks driving cell growth and division through multiple promoter-binding modes.
Authors propose that Sfp1p serves as a part of a regulatory complex, and the activity of this complex may be modulated differently by the absence or prionization of Sfp1p.
Title: Transcriptional response to the [ISP(+) ] prion of Saccharomyces cerevisiae differs from that induced by the deletion of its structural gene, SFP1.
we may state that SFP1 participates in the control of translation termination by means of regulation of Sup35p level
Title: [SFP1 controls translation termination in Saccharomyces cerevisiae via regulation of the Sup35p (eRF3) level].
Show that the level of SUP35 transcription in [ISP+] cells containing the sup35 mutation is increased relative to [isp-] cells and cells with a SFP1 deletion.
Title: SUP35 expression is enhanced in yeast containing [ISP+], a prion form of the transcriptional regulator Sfp1.
show that SFP1 deletion causes an irreversible [ISP(+)] loss, whereas increased SFP1 expression induces [ISP(+)] appearance.
Title: Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1.
Studies confirmed the promoter occupancy of RPS3 by Rap1p and other transcription factors Sfp1p, Hmo1p and Crf1p.
Title: Determination of the core promoter regions of the Saccharomyces cerevisiae RPS3 gene.
while Sfp1 is necessary for the efficient glucose-dependent regulation of ribosome biogenesis genes, it is not required for the proper induction of ribosomal protein genes in response to glucose excess
Title: Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis.
These results suggest that Sfp1 plays a role in transcriptional and cell size control, operating at two different levels of the regulatory network linking growth, metabolism and cell size.
Title: Revisiting the role of yeast Sfp1 in ribosome biogenesis and cell size control: a chemostat study.
SFP1 is involved in cell size modulation in respiro-fermentative growth conditions.
Title: SFP1 is involved in cell size modulation in respiro-fermentative growth conditions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc-coordinating transcription factor SFP1

NP_013507.1

Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

925568..927619

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182291.1 → NP_013507.1 TPA: zinc-coordinating transcription factor SFP1

See identical proteins and their annotated locations for NP_013507.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZ36, P32432

UniProtKB/TrEMBL

A7A1S6, C8ZE12, G2WJL6, N1NZU0

Conserved Domains (2) summary

COG5189
Location:43 → 683

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:600 → 629

ZF_C2H2; C2H2 Zn finger [structural motif]