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RPL2A 60S ribosomal protein uL2 RPL2A [ Saccharomyces cerevisiae S288C ]

Gene ID: 850590, updated on 12-Aug-2025
Official Symbol
RPL2A
Official Full Name
60S ribosomal protein uL2 RPL2A
Primary source
SGD:S000002104
Locus tag
YFR031C-A
See related
AllianceGenome:SGD:S000002104; FungiDB:YFR031C-A; VEuPathDB:YFR031C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RPL5B
Summary
A structural constituent of ribosome. Involved in cytoplasmic translation; maintenance of translational fidelity; and ribosomal large subunit biogenesis. Part of cytosolic large ribosomal subunit. Used to study Diamond-Blackfan anemia. Orthologous to human RPL8 (ribosomal protein L8). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See RPL2A in Genome Data Viewer
Location:
chromosome: VI
Exon count:
2
Sequence:
Chromosome: VI; NC_001138.5 (220507..221418, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene sulfite reductase subunit alpha Neighboring gene condensin subunit SMC2 Neighboring gene ncRNA Neighboring gene Rrt5p

Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure/function analysis of yeast ribosomal protein L2. Meskauskas A, et al. Nucleic Acids Res, 2008 Apr. PMID 18263608, Free PMC Article
  2. The ABF1 factor is the transcriptional activator of the L2 ribosomal protein genes in Saccharomyces cerevisiae. Della Seta F, et al. Mol Cell Biol, 1990 May. PMID 2183035, Free PMC Article
  3. Characterisation of Saccharomyces cerevisiae genes encoding ribosomal protein YL6. Moore J, et al. Mol Gen Genet, 1995 Apr 20. PMID 7753035
  4. The amino terminal domain from Mrt4 protein can functionally replace the RNA binding domain of the ribosomal P0 protein. Rodríguez-Mateos M, et al. Nucleic Acids Res, 2009 Jun. PMID 19346338, Free PMC Article
  5. Introns provide a platform for intergenic regulatory feedback of RPL22 paralogs in yeast. Abrhámová K, et al. PLoS One, 2018. PMID 29304067, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of translational fidelity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
60S ribosomal protein uL2 RPL2A
NP_116688.3
  • Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    220507..221418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180030.3 → NP_116688.3  TPA: 60S ribosomal protein uL2 RPL2A

    See identical proteins and their annotated locations for NP_116688.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTR2, P05736, P0CX45, P0CX46
    UniProtKB/TrEMBL
    A0A0L8VR97, A6ZVP9, B3LTM6, B3LUP0, C8Z7W6, G2WGC6, N1P6U2
    Conserved Domains (1) summary
    cl40667
    Location:1 → 252
    RplB; Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX45.1
P0CX46.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous