Nature Biotechnology Nature Biotechnology is a monthly journal publishing new concepts in biological technology of relevance to bioengineering, medicine, energy, agriculture, food and the environment. It has a magazine covering the commercial, political, ethical, legal and societal aspects of this research. http://feeds.nature.com/nbt/rss/current Nature Publishing Group en © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Biotechnology © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. [email protected]
  • Nature Biotechnology https://www.nature.com/uploads/product/nbt/rss.png http://feeds.nature.com/nbt/rss/current <![CDATA[Deep learning speeds the search for new antibiotic scaffolds]]> https://www.nature.com/articles/s41587-025-02806-6 <![CDATA[
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    Nature Biotechnology, Published online: 24 October 2025; doi:10.1038/s41587-025-02806-6

    A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds.]]> <![CDATA[Deep learning speeds the search for new antibiotic scaffolds]]> Yumeng ZhangJiangning SongCesar de la Fuente-Nunez doi:10.1038/s41587-025-02806-6 Nature Biotechnology, Published online: 2025-10-24; | doi:10.1038/s41587-025-02806-6 2025-10-24 Nature Biotechnology 10.1038/s41587-025-02806-6 https://www.nature.com/articles/s41587-025-02806-6 <![CDATA[Democratizing protein language model training, sharing and collaboration]]> https://www.nature.com/articles/s41587-025-02859-7 <![CDATA[

    Nature Biotechnology, Published online: 24 October 2025; doi:10.1038/s41587-025-02859-7

    SaprotHub is a community repository for protein language models.]]>     <![CDATA[Democratizing protein language model training, sharing and collaboration]]> Jin SuZhikai LiTianli TaoChenchen HanYan HeFengyuan DaiQingyan YuanYuan GaoTong SiXuting ZhangYuyang ZhouJunjie ShanXibin ZhouXing ChangShiyu JiangDacheng MaAnthony GitterMilot MirditaKevin K. YangPascal NotinDebora S. MarksPranam ChatterjeeRohit SinghPhilip A. RomeroMichael HeinzingerJianming LiuJia ZhengStan Z. LiAnping ZengHuaizong ShenJijie ChaiFeng JuNoelia FerruzAnum GlasgowPhilip M. KimChristopher SnowVasilis NtranosJianyi YangLiang HongCaixia GaoTong SiMichael BronsteinXing ChangFajie YuanJin SuZhikai LiTianli TaoChenchen HanYan HeFengyuan DaiXuting ZhangYuyang ZhouJunjie ShanXibin ZhouShiyu JiangYuan GaoJiawei ZhangYuliang FanYuyang TaoLinqi ChengXinzhe ZhengLei ChenRui LongLingjie KongZhongji PuJiaming GuanTianyuan ZhangCheng LiMartin SteineggerSergey OvchinnikovFajie Yuan doi:10.1038/s41587-025-02859-7 Nature Biotechnology, Published online: 2025-10-24; | doi:10.1038/s41587-025-02859-7 2025-10-24 Nature Biotechnology 10.1038/s41587-025-02859-7 https://www.nature.com/articles/s41587-025-02859-7     <![CDATA[Deep-learning-based virtual screening of antibacterial compounds]]> https://www.nature.com/articles/s41587-025-02814-6 <![CDATA[

    Nature Biotechnology, Published online: 24 October 2025; doi:10.1038/s41587-025-02814-6

    Antibacterial compounds are discovered by combining phenotypic screening with deep learning.]]>     <![CDATA[Deep-learning-based virtual screening of antibacterial compounds]]> Gabriele ScaliaSteven T. RutherfordZiqing LuKerry R. BuchholzNicholas SkeltonKangway ChuangNathaniel DiamantJan-Christian HütterJerome-Maxim LuescherAnh MiuJeff BlaneyLeo GendelevElizabeth SkippingtonGreg ZyndaNia DicksonMicha KoziarskiYoshua BengioAviv RegevMan-Wah TanTommaso Biancalani doi:10.1038/s41587-025-02814-6 Nature Biotechnology, Published online: 2025-10-24; | doi:10.1038/s41587-025-02814-6 2025-10-24 Nature Biotechnology 10.1038/s41587-025-02814-6 https://www.nature.com/articles/s41587-025-02814-6     <![CDATA[Long-term imaging of cell divisions in human preimplantation embryos]]> https://www.nature.com/articles/s41587-025-02841-3 <![CDATA[

    Nature Biotechnology, Published online: 23 October 2025; doi:10.1038/s41587-025-02841-3

    An optimized approach for live imaging of human embryos enables visualization of mitotic errors during blastocyst development.]]>     <![CDATA[Long-term imaging of cell divisions in human preimplantation embryos]]> Corentin MollierJean-Léon Maître doi:10.1038/s41587-025-02841-3 Nature Biotechnology, Published online: 2025-10-23; | doi:10.1038/s41587-025-02841-3 2025-10-23 Nature Biotechnology 10.1038/s41587-025-02841-3 https://www.nature.com/articles/s41587-025-02841-3     <![CDATA[Overcoming barriers to the wide adoption of single-cell large language models in biomedical research]]> https://www.nature.com/articles/s41587-025-02846-y <![CDATA[

    Nature Biotechnology, Published online: 23 October 2025; doi:10.1038/s41587-025-02846-y

    Transformer-based large language models are gaining traction in biomedical research, particularly in single-cell omics. Despite their promise, the application of single-cell large language models (scLLMs) remains limited in practice. In this Comment, we examine the current landscape of scLLMs and the benchmark studies that assess their applications in various analytical tasks. We highlight existing technical gaps and practical barriers, and discuss future directions toward a more accessible and effective ecosystem to promote the applications of scLLMs in the biomedical community.]]>     <![CDATA[Overcoming barriers to the wide adoption of single-cell large language models in biomedical research]]> Fang XieBingkang ZhaoSongxiang XuZehua WangJames J. MoonLana X. Garmire doi:10.1038/s41587-025-02846-y Nature Biotechnology, Published online: 2025-10-23; | doi:10.1038/s41587-025-02846-y 2025-10-23 Nature Biotechnology 10.1038/s41587-025-02846-y https://www.nature.com/articles/s41587-025-02846-y     <![CDATA[RNA structure modulates Cas13 activity and enables mismatch detection]]> https://www.nature.com/articles/s41587-025-02868-6 <![CDATA[

    Nature Biotechnology, Published online: 23 October 2025; doi:10.1038/s41587-025-02868-6

    An effective CRISPR RNA occlusion strategy enhances mismatch detection when using Cas13.]]>     <![CDATA[RNA structure modulates Cas13 activity and enables mismatch detection]]> Benjamin B. LarsenOfer KimchiOwen R. S. DunkleyMaaike S. GrimmJurre Y. SiegersYujia HuangVenu G. VandavasiLong T. NguyenCaitlin H. LambIrina AranovichDirk EgginkAdam MeijerHamid JalalDaniel A. NottermanErik A. KarlssonAartjan J. W. te VelthuisCameron Myhrvold doi:10.1038/s41587-025-02868-6 Nature Biotechnology, Published online: 2025-10-23; | doi:10.1038/s41587-025-02868-6 2025-10-23 Nature Biotechnology 10.1038/s41587-025-02868-6 https://www.nature.com/articles/s41587-025-02868-6     <![CDATA[Elucidating lipid nanoparticle properties and structure through biophysical analyses]]> https://www.nature.com/articles/s41587-025-02855-x <![CDATA[

    Nature Biotechnology, Published online: 23 October 2025; doi:10.1038/s41587-025-02855-x

    Guidance for optimizing lipid nanoparticle formulations is derived using sophisticated biophysical techniques.]]>     <![CDATA[Elucidating lipid nanoparticle properties and structure through biophysical analyses]]> Marshall S. PadillaSarah J. ShepherdAndrew R. HannaMartin KurnikXujun ZhangMichelle ChenJames ByrnesRyann A. JosephHannah M. YamagataAdele S. RicciardiKaitlin MrksichDavid IssadoreKushol GuptaMichael J. Mitchell doi:10.1038/s41587-025-02855-x Nature Biotechnology, Published online: 2025-10-23; | doi:10.1038/s41587-025-02855-x 2025-10-23 Nature Biotechnology 10.1038/s41587-025-02855-x https://www.nature.com/articles/s41587-025-02855-x     <![CDATA[Discovery and engineering of retrons for precise genome editing]]> https://www.nature.com/articles/s41587-025-02879-3 <![CDATA[

    Nature Biotechnology, Published online: 23 October 2025; doi:10.1038/s41587-025-02879-3

    A metagenomic screen identifies retron reverse transcriptases for precise genome-editing applications.]]>     <![CDATA[Discovery and engineering of retrons for precise genome editing]]> Jesse D. BuffingtonHung-Che KuoKuang HuYou-Chiun ChangKamyab JavanmardiBrittney VoigtYi-Ru LiMary E. LittleSravan K. DevanathanBlerta XhemalçeRyan S. GrayIlya J. Finkelstein doi:10.1038/s41587-025-02879-3 Nature Biotechnology, Published online: 2025-10-23; | doi:10.1038/s41587-025-02879-3 2025-10-23 Nature Biotechnology 10.1038/s41587-025-02879-3 https://www.nature.com/articles/s41587-025-02879-3