tRNA modifications are key regulators of translational reprogramming, although their role in colorectal cancer (CRC) is poorly understood. We show an oncogenic role for TRMT6 in CRC, revealing that TRMT6-mediated tRNA m1A modification functions as a critical translational checkpoint that is essential for rapid histone synthesis in CRC cells.
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References
Wang, Y. et al. tRNA modifications: insights into their role in human cancers. Trends Cell Biol. 33, 1035–1048 (2023). This review article describes the roles of various tRNA modifications in human cancers.
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This is a summary of: Tao, E.-W. et al. TRMT6-mediated tRNA m1A modification acts as a translational checkpoint of histone synthesis and facilitates colorectal cancer progression. Nat. Cancer https://doi.org/10.1038/s43018-025-00977-4 (2025).
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Targeting the tRNA m1A modifier TRMT6 for colorectal cancer therapy. Nat Cancer 6, 1307–1308 (2025). https://doi.org/10.1038/s43018-025-00978-3
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DOI: https://doi.org/10.1038/s43018-025-00978-3
