%PDF-1.4 %âãÏÓ 1 0 obj <> endobj 2 0 obj <>stream uuid:bdca94b2-bccc-4886-8f11-11af979bff99 adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31 xmp.id:335dd48e-b4d3-fc4c-9ef6-e97d35b5cc69 proof:pdf 1 xmp.iid:a7ff9c0f-7cc9-dd43-a8da-fb870507ad21 xmp.did:ba2d4b75-d332-474d-bfad-908ad9d497fc default

converted from application/x-indesign to application/pdf Adobe InDesign 18.0 (Windows) 2025-06-17T15:10:56+02:00

converted uuid:0a20cc00-28e7-4b59-8a51-7b4b9a9e1278 converted to PDF/A-2b pdfToolbox 2025-06-17T18:08:01+02:00

2025-06-17T15:10:56+02:00 2025-06-18T10:03:18+02:00 2025-06-18T10:03:18+02:00 Adobe InDesign 18.0 (Windows) journal 10.1186/s12959-025-00753-5 2010-04-23 true

springer.com

springerlink.com

2010-04-23 true 10.1186/s12959-025-00753-5

springer.com

springerlink.com

http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management

internal UUID based identifier for specific incarnation of a document InstanceID URI

internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI

internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef

internal An unordered array of references to resources that were incorporated, by inclusion or reference, into this document. Ingredients Bag ResourceRef

Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part

http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF

internal A name object indicating whether the document has been modified to include trapping information Trapped Text

http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text

internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text

http://ns.adobe.com/pdfx/1.3/ pdfx pdfx

internal ID of PDF/X standard GTS_PDFXVersion Text

internal Conformance level of PDF/X standard GTS_PDFXConformance Text

internal Company creating the PDF Company Text

internal Date when document was last modified SourceModified Text

external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text

external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text

external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text

internal Mirrors crossmark:DOI doi Text

http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema

internal Part of PDF/A standard part Integer

internal Amendment of PDF/A standard amd Text

internal Conformance level of PDF/A standard conformance Text

http://crossref.org/crossmark/1.0/ crossmark crossmark

internal CrossMarkDomains CrossMarkDomains Seq Text

internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text

internal Usual same as prism:doi DOI Text

external The date when a publication was published. MajorVersionDate Text

http://prismstandard.org/namespaces/basic/2.0/ prism Prism

external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at [email protected] to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text

http://www.niso.org/schemas/jav/1.0/ jav NISO

external Values for Journal Article Version are one of the following: AO = Authorâ€™s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text

endstream endobj 3 0 obj <>/LastModified(þÿ D : 2 0 2 5 0 6 1 7 1 3 1 0 5 8 Z)/PageWidthList<0 595.276>>/PageItemUIDToLocationDataMap<0[1807.0 28.0 3.0 -124.724 -361.85 -56.6929 -353.346 1.0 0.0 0.0 1.0 -233.858 -351.675]/1[1829.0 42.0 3.0 470.551 -361.85 538.583 -353.346 1.0 0.0 0.0 1.0 225.357 -351.675]/2[1851.0 56.0 3.0 -538.583 -361.85 -124.724 -353.346 1.0 0.0 0.0 1.0 -233.858 -351.675]/3[1873.0 58.0 3.0 56.6929 -361.85 470.551 -353.346 1.0 0.0 0.0 1.0 225.357 -351.675]/4[2876.0 0.0 2.0 -538.583 -312.851 -304.724 336.85 1.0 0.0 0.0 1.0 -300.472 -151.063]/5[2898.0 1.0 2.0 -290.551 -312.85 -56.6929 336.85 1.0 0.0 0.0 1.0 -290.051 -312.35]/6[2920.0 2.0 2.0 56.6929 -312.85 290.551 336.85 1.0 0.0 0.0 1.0 57.1929 -312.35]/7[2942.0 3.0 2.0 304.724 -312.85 538.583 336.85 1.0 0.0 0.0 1.0 305.224 -312.35]/8[8324.0 7.0 4.0 56.6929 -312.85 538.613 52.1896 1.0 0.0 0.0 1.0 56.6929 -312.85]/9[8327.0 6.0 0.0 56.6929 -312.85 538.613 52.1896 1.0 0.0 0.0 1.0 297.653 -130.33]/10[8348.0 8.0 2.0 56.708 52.1896 538.598 100.189 1.0 0.0 0.0 1.0 5.01512 -391.85]/11[8780.0 9.0 2.0 56.6929 -312.85 68.0315 -301.512 1.0 0.0 0.0 1.0 5.0 -391.85]>>/NumberofPages 1/NumberOfPageItemsInPage 12/OriginalDocumentID(þÿ a d o b e : d o c i d : i n d d : a c a 9 e 6 a 3 - b 7 b c - 1 1 d d - 9 b 3 1 - 8 d 9 2 e d e d 7 c 3 1)/DocumentID(þÿ x m p . d i d : b a 2 d 4 b 7 5 - d 3 3 2 - 4 7 4 d - b f a d - 9 0 8 a d 9 d 4 9 7 f c)/PageUIDList<0 2855>>>>>>/CropBox[0.0 0.0 595.276 793.701]/TrimBox[0.0 0.0 595.276 793.701]>> endobj 6 0 obj [9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R] endobj 5 0 obj <>/ExtGState<>/ProcSet[/PDF/Text]/Font<>/XObject<>>> endobj 8 0 obj <>stream xœµ]{oÜF’ÿ_áÖIøÏ@¢ÙÝ|fÛÙÍ"ÆyÏÊVp 4c‰›Ž2+ÊÙÏq÷ï®ªd5»ÉiéölXž'ÙU]Ï_Uµ¢—¯v‡öSssøã_þóËšÇíñðÍ7ß¾y}öíåÙË×Òèf–FøwÓ½ü¼r»?{yÉþ#Xtùé,I‹,º|8«ä‡ª(«‹$Ïr–fu•9Oê<Ò¼ÀOmÎ>Æï¼ˆ›ÛUÄ£í§h‘ä1c‹Ÿ.ÿrööòìí»×g¿Àíàrp'†w‚'?œ½ün“Fo¶g={ùúCÓÝÆ«îâÇ‹—ï^ÿ&ªÙ°fXS+“×ai"äÊäƒ¼HŠZDE]&ešÖ¼,…^Ö÷‹w‹">ìU¼]\ÀÂãåñfqÁàµvÛÑ5N¬‚[«à†?Ç…Ô‰âþo–Qåãe¼Zð<>À2îV;ø ë(ãýâ"‡ÅÜ,òx^=´7¬¬Š|ºl·Ÿa™iÜÀO–T5þ)X…_,àkðã¸†kÀ§£e‹ä«ÅEíÿÊ*º‚…\°:þ 7!ï¾&Õñ¿âß\-` À©nQBØ#zö¤c†ðª 9ÉJÆj–¹|‰/—;qõ¬¿z’f“/^™Êãq%y!Ó·Ñ5Í Å«¨‰6Í¢NXü7dÍvG¨ÞÁ7acÚë£üòN_c³Ý]·Ëöð5ÝŸá5aSáëÍ_àU>PÃ³|Šš‚©yØ¢D¬—°¹„Œv¹:¤´Rº" )¾¿W2þk‹TJÉ[-ÊxýXˆú+Ðƒ,SU]Ä›v½eˆÚnÙ~ßã@X,câB„ ØÆÄ$Û²zÌ¶FêÇ>j¾”¸`™Ò›Cÿt $G¯ñSwm×DÍzÛ¢W„`4™ÚŒãf¯•E’²”Õ¼*™»Ð˜fAmÝÏ6Û>¦°*Mj^—u&˜ç–ãŸ¤Í‹¶=Ëè^™“_Ž«H‹<½ÅyØ)Þ¡ý:É%–¦Árá0å´\ G‰`Ôå”`ˆrLü^ »©Ç{mŽf&PJòX¾¯Õ…˜±jÅ‹ö-²ŠÅ]û…2â]ÿUÐ»¶“×ÔÜSš`.½ÃïÁm3xm~ágéKØ<¸¨$ãÕxîðá ÷ùg¸XËVÒ ¶Ým´?^Ëý>¨Å*ºsÖ@™²Žw+Û§4kÉ—ÁÔåÍ•ø Ò1™i=Es éÝ çàò+²‰¿ÕúÑn×í'¹Ä Í‡èiª_%¹Èy w1ò|N÷=La•H²<+ê¢Èso@÷ÿÅ˜Cp†rC£ZÆ{p)›v»îUŸÅíò‡Í:h¿ ¢’“þ:u<ÜJ&*à5traÒ)¢jhüú|u™à]¯Óæ C }]éé-ë‡JÜRVNi]^9¦w"Æã£È Ävz™z—Œ‰Èµ¸~Œøß³èÐn•<‹Ï£c·\íúônBPj¢‚¬uMD£˜Rå¼t¬5!