See More

%PDF-1.4 %âãÏÓ 1 0 obj <> endobj 2 0 obj <>stream uuid:8f30d20b-3679-457c-960e-2bbc2321da07 adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31 xmp.id:0c668c0e-c632-7e48-ab67-8e243897c009 proof:pdf 1 xmp.iid:ccaecb32-6307-804f-8c94-02b550648f0c xmp.did:b3cfbb87-11b8-004b-8fab-50a9ab50338b default

  • converted from application/x-indesign to application/pdf Adobe InDesign 18.3 (Windows) 2025-05-23T11:36:58+02:00
  • converted uuid:a2ffc91c-5c2f-4909-bf5c-de312b01100a converted to PDF/A-2b pdfToolbox 2025-05-23T13:39:27+02:00
  • 2025-05-23T11:36:58+02:00 2025-05-23T14:49:10+02:00 2025-05-23T14:49:10+02:00 Adobe InDesign 18.3 (Windows) journal 10.1186/s12959-025-00743-7 2010-04-23 true
  • springer.com
  • springerlink.com
  • 2010-04-23 true 10.1186/s12959-025-00743-7
  • springer.com
  • springerlink.com
  • VoR application/pdf Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) False 2 B
  • http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management
  • internal UUID based identifier for specific incarnation of a document InstanceID URI
  • internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI
  • internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef
  • internal An unordered array of references to resources that were incorporated, by inclusion or reference, into this document. Ingredients Bag ResourceRef
  • Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part
  • http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF
  • internal A name object indicating whether the document has been modified to include trapping information Trapped Text
  • http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text
  • internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text
  • http://ns.adobe.com/pdfx/1.3/ pdfx pdfx
  • internal ID of PDF/X standard GTS_PDFXVersion Text
  • internal Conformance level of PDF/X standard GTS_PDFXConformance Text
  • internal Company creating the PDF Company Text
  • internal Date when document was last modified SourceModified Text
  • external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text
  • external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text
  • external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text
  • internal Mirrors crossmark:DOI doi Text
  • http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema
  • internal Part of PDF/A standard part Integer
  • internal Amendment of PDF/A standard amd Text
  • internal Conformance level of PDF/A standard conformance Text
  • http://crossref.org/crossmark/1.0/ crossmark crossmark
  • internal CrossMarkDomains CrossMarkDomains Seq Text
  • internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text
  • internal Usual same as prism:doi DOI Text
  • external The date when a publication was published. MajorVersionDate Text
  • http://prismstandard.org/namespaces/basic/2.0/ prism Prism
  • external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at [email protected] to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text
  • http://www.niso.org/schemas/jav/1.0/ jav NISO
  • external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text
  • endstream endobj 3 0 obj <>/LastModified(þÿ D : 2 0 2 5 0 5 2 3 0 9 3 7 3 0 Z)/PageWidthList<0 595.276>>/PageItemUIDToLocationDataMap<0[1807.0 28.0 3.0 -124.724 -361.85 -56.6929 -353.346 1.0 0.0 0.0 1.0 -233.858 -351.675]/1[1829.0 27.0 3.0 470.551 -361.85 538.583 -353.346 1.0 0.0 0.0 1.0 225.357 -351.675]/2[1851.0 26.0 3.0 -538.583 -361.85 -124.724 -353.346 1.0 0.0 0.0 1.0 -233.858 -351.675]/3[1873.0 25.0 3.0 56.6929 -361.85 470.551 -353.346 1.0 0.0 0.0 1.0 225.357 -351.675]/4[2876.0 0.0 2.0 -538.583 -312.851 -304.724 336.85 1.0 0.0 0.0 1.0 -300.472 -151.063]/5[2898.0 1.0 2.0 -290.551 -312.85 -56.6929 336.85 1.0 0.0 0.0 1.0 -290.051 -312.35]/6[2920.0 2.0 2.0 56.6929 -312.85 290.551 336.85 1.0 0.0 0.0 1.0 57.1929 -312.35]/7[2942.0 3.0 2.0 304.724 -312.85 538.583 336.85 1.0 0.0 0.0 1.0 305.224 -312.35]/8[8773.0 4.0 2.0 56.6929 59.8817 538.583 336.85 1.0 0.0 0.0 1.0 5.0 -19.1183]>>/NumberofPages 1/NumberOfPageItemsInPage 9/OriginalDocumentID(þÿ a d o b e : d o c i d : i n d d : a c a 9 e 6 a 3 - b 7 b c - 1 1 d d - 9 b 3 1 - 8 d 9 2 e d e d 7 c 3 1)/DocumentID(þÿ x m p . d i d : b 3 c f b b 8 7 - 1 1 b 8 - 0 0 4 b - 8 f a b - 5 0 a 9 a b 5 0 3 3 8 b)/PageUIDList<0 2855>>>>>>/CropBox[0.0 0.0 595.276 793.701]/TrimBox[0.0 0.0 595.276 793.701]>> endobj 6 0 obj [9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R] endobj 5 0 obj <>/ExtGState<>/ProcSet[/PDF/Text]/Font<>/XObject<>>> endobj 8 0 obj <>stream xœµ]YÜF’~ï¿°–Å$ ¦˜¼‰ k×^Kc%ûÅ2¬®ên®Y¬vj÷þŒy˜ß;‘™d^,fk±6 UWU33"#¾¸SÁ‹—ûcwÝ^ÿò—?¾x×>ìNÇ¿þõ՛ׯ>]¼xý1 ®I€ÿ®†‹ÿ ïÜ.^|bÿ,øt}'e|º¿¨éKuP$I\æuS—5+ƒªHã¦Hê¤(ñkÛ‹_ÃQZ†íÍ&HƒÝuÅEXF¿}ú¯‹·Ÿ.Þ¾}ñ,ƒ•®?¼»xñÛ$x³»øûÅ‹°Ñwípn†ËŸ?F/Þ¿þþMP±iϰ3ÆwFÏaIœÑÎèEQÆe“eSÅU’4iUebW¯¢Ë,l¯~XÞì£:fáî4¬ÕÍ¬jk§‚+,¯qù&æ|Á¿åâua.þKTeðÐÝ)º,ÂCpŒÊðvì¶«è’eáþLãºÁÿJV‡ù~ßE—yÜ„‡mð9 <ê2+ã&ÿX‘á§·Ÿ£ ãÏmƒÃù$ø9¯¢Ë2<îñ³ð´Åcù¯“°¥wLÈF&$&Ùi û)òб†å6õáeôéžžO“ºšãk•á“UQ#ºN=Rßd¾„7#}üç?ãÌo£&<ÝpaZÇ|ô™[…Ÿ‚vXw§~»Z`Z–…Áx$Ì*¼™e’äìReV9Ǭ’™Ìê¹”lãàgT‚;âÄôù ÄíŽxpב[-~ä¹ü¬UëŽËL·&)n{Áìàþv Y~ÙDUØïî&U i1GFÞ˜d̝‹$/€Ã…Ÿ¿løqjºÕ•òc|˜ž•*¸ž*eˇ´z$í2N’YڲʤíÐvkq,|ýM€0ÁÅóŽïh8t«~\ã·öÁI#s#*È; þ!øÕƒ€F`4Â4HÀ6E:‰Ó$-“2M˜MUÈEºN´õtS¤/UÄ,MY“fuêXê·8X^Œ)‚7âi“°’1iaÑw(ßÃQá/îŠS"¨­ÎQVnà †&°Õ!ÿE ŸßåAÚ¸]¦9ÈèÓ á|¿[o|üzĪåã¬S1(fÈvƒ&UPfÁ—MþÓîij—h1Ü÷üÉ_àâß°;÷}ÀeK/¼³ò Ïß6™ÄyÀm­Ú¦Òm›Fæ%s '}‹ÜÉÓŒ N«Ë(ËÏDðm»o‡àå5ˆˆòE.1WøgnÀǏ/?GÏiÐTÖs1áðÜ?àóêKD:5pwð#‘9cÂ4’‹Ú èð×e––gàE[ þ¨«Ò±Hº¼HuS@ ˜IV™ÇuR±¦**{Á_ZÞÃ)î׏¨ƒ$Ñ›€ÛîPuÂ,’사又¿xÄAKXj°Ì}À€pÌéqtÚç… !Ÿûãd‰â;deY£{ÜîUÐ)@®M'sÇ=Ëã‚ É™Þ^-˜ß‚.˝M¯º[$y¨{3™¢˜±–•–up;O_ŽÜåXÉß'þž?f3Œ=#G•eÏ¢©F4Es^:sËÄrAø„ðø6G»G÷¡ ÿØm¾ Îh|ÏÐ= %K®`ð˜g>nsS=ÎmÎ⬩²¤ÎòƦËÃÄ5µ·Û\Ç+ë&/2Ñ”,®u.$p7Ejšìrq –œ‹b–X¢AnÉÒ¼x ²—$uøMì½O÷˜ˆ±¤}P)2á銫Cw|@)è©BQ…ñ›R´¡c$eäh©N=˜¹·JÀ’%€¦2ËFsáwg}ΘKࣦ cŸ]ª±ËNm4±,ãL3rèVäj&c§9Ë`ïƒMzGsGÉ‘ñO/ƒ%ÞQ…E¬‡›Á%¬`µ…óâÀóÆBø­å)^z ü*ûgú,¸íÐÍG±¦÷À÷Ç¿îœÜ$ÉÀUéˆâ2Ôœü‚Šø†žvWñàåR4”Ö®Ó&xàÉÕj£ùJ ø(Á¨ªrÍßàƒe5Z÷<ÉsVÛû+C>ƒhkåØõ2IŠìŸ½Öo±ÇbµåÏ(f^Z Ši¦ŸQ;yj•¢RרøœB®”íŠôÝð;Äqv0Î!ãš,ž/'Ißíy@ÝÔ`Nüb€ÉdžÖº« ÛnÑš ?üqÌ¹/ÓÊ_ð±ö¦¦Àf‚àen‡7Ýn —¨¾¼Ør@¢øa mÝß•Œ„Â5óóB³s±‡Í½þdE’¤ Ö6‰aíÁ½sqˆ‹Ÿ° I^&Y];Ö$7åeÄéݧn¯È–ÔUb™dyš™eJÖ›'Ò×ÙÓ, !h DíÍ&J7]7è͏ô üûõdpÊÐB|sÁÌ”†™ñ ¹PhÎæ*qyjp`Ç2刯ñ}¦Hå!b¼å–²%W¯#):Õ(¿ÕíÛ^ZI´Ääxpý9|‰4þ¥Mø‰Å$÷%…ÿÒiå¬WGïÁRu&f±1±k)D„ÐÊÆfÎ@Ùo»€!æž´Hr,·´=Ou^*®—DÝÿ4hüå#òQ>œQªL¬°r~‚3YcY ¹ÅEC¨»^€U?°ÀE“WMRæMnï4l<