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Editors' Pick: SARS-CoV-2 COVID-19 Susceptibility and Lung Inflammatory Storms by Smoking and Vaping
Aging, smoking/vaping results in severe disease outcome and mortality amongst COVID-19 patients. SARS-CoV-2 with a membrane spike glycoprotein furin along with its receptor ACE2 and TMPRSS2 protease are increased by smoking/vaping in lung epithelium rendering viral entry and augmented infection. This results in a ‘cytokine storm’ involving excessive production of pro-inflammatory cytokines/chemokines. This review therefore discusses the impact of smoking /vaping on the key inflammatory mechanisms following Covid-19 infection and the possible therapeutic strategies required to overcome this excessive inflammatory response.
From theory to therapy; understanding and targeting immunometabolism for the treatment of inflammation and cancer
Edited by:
Dr. Peter Bunyard, Ph.D., Sitryx Therapeutics, United Kingdom
Dr. pharm. Marina Makrecka-Kuka, Ph.D., Sitryx Therapeutics, United Kingdom
Submission Status: closed
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Editor-in-Chiefs' profiles
Prof. Paul Kirkham, PhD, FHEA, FRSB, Professor of Cell Biology, University of Wolverhampton, United Kingdom
Professor Kirkham is Professor of Cell Biology at the University of Wolverhampton and a fellow of the HEA. His research interests focus on understanding the mechanisms of disease pathogenesis driven by oxidative stress and its impact on cell function and inflammation, particularly in relation to respiratory disease.
Prof. Adriano Rossi, PhD, DSc, FBS, FBPhS, University of Edinburgh, United Kingdom
Professor Rossi holds the position of Personal Chair in Respiratory and Inflammation Pharmacology at the University of Edinburgh. He is a Fellow of the Society of Biology and a Fellow of the British Pharmacological Society. His research involves investigating the cellular processes and signalling mechanisms controlling inflammation with a focus on understanding inflammation resolution.
Affiliated with the British Inflammation Research Association (BIRAs).
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Citation Impact
Journal Impact Factor: 4.1 (2024)
5-year Journal Impact Factor: 4.4 (2024)
Source Normalized Impact per Paper (SNIP): 0.881 (2024)
SCImago Journal Rank (SJR): 1.214 (2024)Speed
Submission to first editorial decision (median days): 18
Submission to acceptance (median days): 199Usage 2024
Downloads: 416,662
Altmetric mentions: 166