Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency
By Vrinda Venu, Eric M. Small, Cullen Roth, Samantha H. Adikari, Anna Hendrika Cornelia Vlot, Kyle A. Sullivan, Chanaka Roshan Abeyratne, Daniel Jacobson, Shawn R. Starkenburg, Karissa Y. Sanbonmatsu & Christina R. Steadman
This new research in Epigenetics & Chromatin reports on how histone deacetylase inhibitor treatment in lung cancer cells alters chromatin structure and gene expression. The study reveals complex interactions among chromatin features that support transcriptional regulation. Read full article here.
H2A.X N-terminal acetylation is a newly identified NAA40-mediated modification that is responsive to UV irradiation
By Ariel Klavaris, Costas Koufaris, Roberta Noberini, Maria Kouma, Christina Demetriadou, Alessandro Ghiringhelli, Nikolas Dietis, Tiziana Bonaldi & Antonis Kirmizis
Our findings identify H2A.X as a novel bona fide substrate of NAA40. Moreover, the responsiveness of H2A.X N-terminal acetylation to UV-induced DNA damage indicates that this is a dynamic modification with potential biological functions. Read full article here.
The multitalented TIP60 chromatin remodeling complex: wearing many hats in epigenetic regulation, cell division and diseases
By Maria Virginia Santopietro, Diego Ferreri, Yuri Prozzillo, Patrizio Dimitri & Giovanni Messina
This new review in Epigenetics & Chromatin discusses the TIP60 complex, a key player in DNA repair and transcription regulation, highlighting its roles across species and its implications in cancer and neurodevelopmental disorders. Read full article here.
Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine
By Karishma Sahoo, Prakash Lingasamy, Masuma Khatun, Sajitha Lulu Sudhakaran, Andres Salumets, Vino Sundararajan & Vijayachitra Modhukur
Epigenetics & Chromatin is pleased to announced publication of a new review article, which is synthesizing current advancements in this field and envisions a future where “AI-powered epigenetic diagnostics can enable earlier detection, more effective treatments, and improved patient outcomes, globally”. Read full article here.
H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation
by Kei Fukuda, Chikako Shimura & Yoichi Shinkai
“In this study, we successfully analysed the transcription, epigenome and 3D genome organization in mammalian cells that, for the first time, lacked all three major repressive chromatin modifications: H3K9 methylation, H3K27me3, and uH2A. Our findings revealed that, in the absence of H3K9 methylation, H3K27me3 and PRC1-uH2A can independently or some inter-dependently contribute to maintain gene/TE silencing and nuclear compartments”. Read full article here.