PARP inhibitor olaparib induces DNA damage and acts as a drug sensitizer in an in vitro model of canine hematopoietic cancer

Table 1 The cytotoxic effects of Olaparib after 48, 72, and 96 h of incubation on the canine lymphoma/leukemia cell lines, expressed as IC₅₀ values. The results are presented as mean ± standard deviation (SD) of 3 independent experiments, each performed in triplicates. Statistical differences were analyzed using a one-way ANOVA followed by the tukey’s multiple comparison test. Values without common letters (a, b, c) in the superscript differ statistically (P <.05)

See More IC₅₀ (µM) values after olaparib treatment of canine lymphoma/leukemia cell lines
	CLBL-1	CLB70	CNK-89	GL-1
48 h	5.60^a ± 1.69	4.82^a ± 0.84	4.29^a ± 0.14	> 33.3^b
72 h	2.68^a ± 0.81	3.03^a ± 1.37	2.03^b ± 0.28	6.83^c ± 1.57
96 h	1.2^a ± 0.17	2.09^a ± 1.44	1.50^a ± 0.63	5.57^b ± 1.34

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