Most Recent Articles: Biology Directhttps://biologydirect.biomedcentral.comMost Recent Articles: Biology DirectRGS16-driven cancer-associated fibroblasts promote esophageal squamous cell carcinoma progression via the MDK-SDC1 axis-mediated intercellular crosstalkhttps://biologydirect.biomedcentral.com/articles/10.1186/s13062-025-00694-zCancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment (TME) and have important roles in carcinogenesis and metastasis by facilitating cancer cell proliferation, angiogenesi...ResearchWed, 15 Oct 2025 00:00:00 GMThttps://biologydirect.biomedcentral.com/articles/10.1186/s13062-025-00694-zDi Wu, Mingzhi Cao, Changgang Yang, Wanshun Li, Deyu Zhang, Shihua Yao, Hong Yu and Gengxi Jiang2025-10-15T00:00:00ZIndispensable role of AcrEF in modulating Salmonella virulence and disrupting host tight junctions to facilitate paracellular entry and invasionhttps://biologydirect.biomedcentral.com/articles/10.1186/s13062-025-00695-yThe Salmonella stress response regulator CpxR controls the AcrEF drug efflux pump, which is crucial for key virulence traits such as invasiveness and disruption of the host paracellular pathway. Understanding the...ResearchWed, 15 Oct 2025 00:00:00 GMThttps://biologydirect.biomedcentral.com/articles/10.1186/s13062-025-00695-yPerumalraja Kirthika, Amal Senevirathne, Vijayakumar Jawalagatti, Suyeon Park, Jun Kwon and John Hwa Lee2025-10-15T00:00:00ZMeasles and public health: an integrative approachhttps://biologydirect.biomedcentral.com/articles/10.1186/s13062-025-00693-0Measles, once considered under control in many high-income countries, has experienced a notable resurgence in recent years due to declining vaccination rates, increased vaccine hesitancy, and gaps in public he...ResearchTue, 14 Oct 2025 00:00:00 GMThttps://biologydirect.biomedcentral.com/articles/10.1186/s13062-025-00693-0Francesco Branda, Marta Giovanetti, Nicola Petrosillo, Mohamed Mustaf Ahmed, Maria Perra, Daria Sanna, Giancarlo Ceccarelli, Massimo Ciccozzi, Enrico Bucci and Fabio Scarpa2025-10-14T00:00:00ZStructural and functional insights into Ubl domain-mediated regulation of SARS-CoV-2 PLprohttps://biologydirect.biomedcentral.com/articles/10.1186/s13062-025-00690-3SARS-CoV-2 papain-like protease (PLpro) is essential for viral replication and immune evasion. It contains an N-terminal ubiquitin-like (Ubl) domain, whose involvement in enzymatic function remains poorly unde...ResearchFri, 03 Oct 2025 00:00:00 GMThttps://biologydirect.biomedcentral.com/articles/10.1186/s13062-025-00690-3Rimanshee Arya, Janani Ganesh, Vishal Prashar and Mukesh Kumar2025-10-03T00:00:00ZMINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1https://biologydirect.biomedcentral.com/articles/10.1186/s13062-025-00686-zHepatocellular carcinoma (HCC) is significantly influenced by hepatitis B virus (HBV) infection. However, the roles of ferroptosis and ubiquitination modifications in this context remain poorly understood.ResearchWed, 01 Oct 2025 00:00:00 GMThttps://biologydirect.biomedcentral.com/articles/10.1186/s13062-025-00686-zWenbiao Chen, Yang Song, Liyang Wang, Feng Xiong and Shenggang Zhang2025-10-01T00:00:00Z