Most Accessed Articles: Biology Direct

Most Accessed Articles: Biology Directhttps://biologydirect.biomedcentral.comMost Accessed Articles: Biology DirectThe ancient Virus World and evolution of cellshttps://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-1-29Recent advances in genomics of viruses and cellular life forms have greatly stimulated interest in the origins and evolution of viruses and, for the first time, offer an opportunity for a data-driven explorati...HypothesisTue, 19 Sep 2006 00:00:00 GMThttps://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-1-29Eugene V Koonin, Tatiana G Senkevich and Valerian V Dolja2006-09-19T00:00:00ZThe RNA world hypothesis: the worst theory of the early evolution of life (except for all the others)ahttps://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-7-23The problems associated with the RNA world hypothesis are well known. In the following I discuss some of these difficulties, some of the alternative hypotheses that have been proposed, and some of the problems...CommentFri, 13 Jul 2012 00:00:00 GMThttps://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-7-23Harold S Bernhardt2012-07-13T00:00:00ZA putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of actionhttps://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-1-7All archaeal and many bacterial genomes contain Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR-associated (cas) genes that have been previously implicated in a...ResearchThu, 16 Mar 2006 00:00:00 GMThttps://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-1-7Kira S Makarova, Nick V Grishin, Svetlana A Shabalina, Yuri I Wolf and Eugene V Koonin2006-03-16T00:00:00ZIs evolution Darwinian or/and Lamarckian?https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-4-42The year 2009 is the 200th anniversary of the publication of Jean-Bapteste Lamarck's Philosophie Zoologique and the 150th anniversary of Charles Darwin's On the Origin of Species. Lamarck believed that evolution ...OpinionWed, 11 Nov 2009 00:00:00 GMThttps://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-4-42Eugene V Koonin and Yuri I Wolf2009-11-11T00:00:00ZThe advantages and disadvantages of horizontal gene transfer and the emergence of the first specieshttps://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-6-1Horizontal Gene Transfer (HGT) is beneficial to a cell if the acquired gene confers a useful function, but is detrimental if the gene has no function, if it is incompatible with existing genes, or if it is a s...ResearchMon, 03 Jan 2011 00:00:00 GMThttps://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-6-1Aaron A Vogan and Paul G Higgs2011-01-03T00:00:00Z