February 10, 2026

Acceptability and safety of one versus three months of rifapentine and isoniazid to prevent tuberculosis in people exposed in the household or workplace in Brazil: The Ultra-Curto randomized controlled trial

In a multi-center, randomized controlled trial, Betina Durovni and colleagues assess the acceptability and safety of a short-course tuberculosis preventive therapy taken daily or weekly for different durations by persons recently exposed to tuberculosis.

Image credit: National Institute of Allergy and Infectious Diseases, Unsplash

01/23/2026

Research Article

Pregnancy outcomes in women at high risk of preterm birth receiving a vaginal cervical cerclage with, or without, progesterone: A retrospective, secondary analysis of the C-STICH randomised controlled trial data

Victoria Hodgetts Morton and colleagues investigate the association between progesterone treatment versus no treatment on pregnancy outcomes in women at high risk of preterm birth who had received a vaginal cervical cerclage.

Image credit: Amina Filkins, Pexels

Pregnancy outcomes in women at high risk of preterm birth receiving a vaginal cervical cerclage with, or without, progesterone: A retrospective, secondary analysis of the C-STICH randomised controlled trial data

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Browse Issues 2004 – 2026

01/30/2026

Perspective

Beyond the hype: Antibody-Drug Conjugates are advancing faster than our clinical strategy

In this Perspective, Giulia Notini and colleagues discuss why the rapid expansion of antibody-drug conjugates, while redefining treatment options in advanced breast cancer, has also resulted in several unresolved challenges, including the need for rational sequencing strategies, appropriate and ethical trial design, drug tolerability, and the limitation of mono-national development programs.

Image credit: National Cancer Institute, Unsplash

Beyond the hype: Antibody-Drug Conjugates are advancing faster than our clinical strategy

02/10/2026

Editorial

Let her shine: Empowering women and closing India’s gender gap in STEM

In recognition of International day of women and girls in STEM, this Editorial by Aparajita Chattopadhyay reflects on the gender gap in STEM in India, outlining socio-cultural and infrastructural factors, recent promising trends, and what is needed to continue these transformations.

Image credit: ThisisEngineering, Unsplash

Let her shine: Empowering women and closing India’s gender gap in STEM

02/05/2026

Research Article

Targeting spinal cord perfusion pressure in acute spinal cord injury through cerebrospinal fluid drainage: A prospective multi-center clinical trial

Cameron M. Gee and colleagues report if targeting spinal cord perfusion pressure via cerebrospinal fluid drainage after acute traumatic spinal cord injury leads to better neurologic recovery, highlighting the challenges of critical care trials.

Image credit: Figure 8; pmed.1004925

02/09/2026

Perspective

Aldosterone synthase inhibitors for hypertension: A breakthrough facing barriers to adoption

In this Perspective, Luke Laffin and Steven Nissen discuss the promise and challenges of aldosterone synthase inhibitors as the next breakthrough in the treatment of uncontrolled hypertension, the number one risk factor for cardiovascular disease.

Image credit: Immo Wegmann, Unsplash

02/02/2026

Research Article

Social inequalities in patient outcomes after total hip replacement surgery for osteoarthritis in England: A population-based cohort study of the National Joint Registry

Rita Patel and colleagues compare area-level socioeconomic differences in multiple outcomes, such as 90-day mortality, among patients aged 50 years and over who underwent primary total hip replacement surgery for osteoarthritis in England.

Image credit: Magda Ehlers, Pexels

02/02/2026

Research Article

Metabolomic insights into associations between adiposity markers and liver cancer risk: Results from a prospective cohort study and Mendelian randomization analysis

By Zhuo-Ying Li and colleagues.

Image credit: buzcajun, Pixabay

01/30/2026

Research Article

Leukemia in users of contemporary hormonal contraception: A nationwide registry-based cohort study among premenopausal women in Denmark

By Caroline H. Hemmingsen and colleagues.

Image credit: Karolina Grabowska www.kaboompics.com, Pexels

02/03/2026

Perspective

The mpox epidemic is not over: Reducing disproportionate burden in Africa and persistent global risk require a sustained response

Rosamund Lewis and colleagues highlight that mpox outbreaks persist across Africa and globally, calling for a sustained, proactive global response.

Image credit: James Wiseman, Unsplash

02/03/2026

Research Article

Mother and child health 4.5 years after gestational diabetes mellitus managed using tight or less tight targets for glycaemic control: Post-hoc follow-up study of the TARGET trial

By Lisa Douglas and colleagues.

Image credit: stanias, Pixabay

Bacterial Antimicrobial Resistance

Antimicrobial Resistance: Addressing a Global Threat to Humanity

In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our PLOS Medicine Editor Philippa C. Dodd discuss the Special Issue dedicated to Antimicrobial resistance and emphasize the urgent threat of AMR.
Global incidence in hospital-associated infections resistant to antibiotics: An analysis of point prevalence surveys from 99 countries

Ruchita Balasubramanian and colleagues, estimate the incidence of hospital-associated infections resistant to antibiotics in 195 countries using point prevalence survey data.
Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)

James Neal Russell and colleagues explore antibiotic use and mortality prediction in hospitalised neonates and infants with sepsis.
Antimicrobial resistance: Strengthening surveillance for public health action

Silvia Bertagnolio, Amitabh Bipin Suthar, Olga Tosas and Kitty Van Weezenbeek discuss surveillance of antimicrobial resistance, the existing limitations and the implications this has on accurate determination of incidence.
Implications of reducing antibiotic treatment duration for antimicrobial resistance in hospital settings: A modelling study and meta-analysis

Yin Mo and colleagues investigate implications of antibiotic duration on antibiotic resistance in hospitals.

PLOS Medicine Collections

COVID-19 Pandemic and Global Mental Health

In this Special Issue, we present a fascinating array of research papers providing insights into various facets of mental health during the pandemic.
Bacterial Antimicrobial Resistance: Surveillance and Prevention

This collection of research articles highlights the multi-faceted challenges imposed by drug-resistant bacteria, the consequences for health and economics, and interventions that could lessen the burden.
Early Detection and Minimal Residual Disease

In this Collection, PLOS Medicine presents high-quality translational research and clinical studies on advances in early cancer detection.
Global Child Health: From Birth to Adolescence and Beyond

This Special Issue brings together the latest research on child and adolescent health, including strategies to monitor and combat child mortality from birth through adolescence, and environmental impacts on child health and mortality.
Maternal and Child Health & Nutrition

This 2019 Special Issue highlights the importance of nutrition for maternal and child health.

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